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[Comparison between two equations to estimated glomerular filtration rate].

S Esteve Poblador1, S Gorriz Pintado, M Ortuño Alonso

  • 1Bioquímica Clínica, Área de Diagnóstico Biológico, Hospital Universitario La Ribera, Valencia, España. sesteve@hospital-ribera.com

Revista Clinica Espanola
|November 29, 2011
PubMed
Summary

The CKD-EPI equation shows slightly lower estimated glomerular filtration rate (eGFR) levels than the MDRD equation, particularly reducing the number of subjects in stage 3 chronic kidney disease. This comparison aids in understanding eGFR calculation differences.

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Area of Science:

  • Nephrology
  • Biostatistics
  • Epidemiology

Background:

  • Estimated glomerular filtration rate (eGFR) is crucial for assessing kidney function.
  • Commonly used equations include the Modification of Diet in Renal Disease (MDRD) study equation and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
  • CKD-EPI includes individuals with normal kidney function, unlike MDRD.

Purpose of the Study:

  • To compare the eGFR results obtained from the MDRD and CKD-EPI equations.
  • To evaluate the impact of each equation on chronic kidney disease (CKD) staging.

Main Methods:

  • Calculated eGFR using both MDRD and CKD-EPI equations for 20,000 subjects.
  • Data included gender, age, and serum creatinine levels.
  • Analyzed differences in eGFR values and CKD stage prevalence between the two equations.

Main Results:

  • CKD-EPI yielded slightly lower eGFR values compared to MDRD (mean difference not specified, but statistically significant).
  • Correlation between equations was high (0.926).
  • CKD-EPI reclassified 2.6% of patients, notably reducing the prevalence of stage 3 CKD.

Conclusions:

  • The CKD-EPI equation provides slightly lower eGFR estimates than the MDRD equation in this population.
  • CKD-EPI application results in a decrease in the number of subjects classified under stage 3 CKD.
  • Both equations showed similar prevalence for other CKD stages.