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Updated: May 27, 2026

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
Published on: September 15, 2014
Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor
José Luis Baeza1, Beatriz G de la Torre, Clara M Santiveri
1Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, Madrid 28006, Spain.
Abstract:
Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas were designed, synthesized and tested. In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini, selected by molecular modeling among various non-proteinogenic cyclic amino acids. NMR conformational studies showed that most of the cyclic peptides were able to adopt turn-like structures. Several of the analogues displayed significant inhibition of the BDNF-induced TrkB receptor phosphorylation, and hence could be useful templates for developing improved antagonists for this receptor.
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