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Updated: May 27, 2026

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle (VLP)-Based Vaccines Using a Capture Assay
Published on: February 10, 2022
Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for
S M Ali Tabei1, Ying Li, Martin Weigert
1James Franck Institute, The University of Chicago, Chicago, IL 60637, United States.
Abstract:
We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo. The model enables us to identify a threshold antibody level that must be achieved to decrease the viral load effectively. Although this threshold has not been reached in existing passive immunization studies, it is within range of humoral immune responses, suggesting that therapeutic vaccines are feasible. In an appendix, we develop a model of passive immunization against influenza, and acute infection.
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