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Radiographic determination of prenatal basicranial ossification.

¹Institute of Orthodontics, Royal Dental College, Copenhagen, Denmark.

Journal of Craniofacial Genetics and Developmental Biology

|January 1, 1990

Summary

This study reveals two distinct ossification patterns in the fetal sphenoid bone, crucial for understanding normal human cranial base development and potential growth deviations.

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Area of Science:

Embryology
Human Anatomy
Developmental Biology

Background:

Previous research elucidated the midsagittal ossification sequence of the human cranial base during prenatal development.
Understanding cranial base ossification is vital for diagnosing developmental abnormalities.

Purpose of the Study:

To identify fetal ossification patterns of the occipital and sphenoid bones using horizontal plane roentgenograms.
To establish developmental stages for these bones correlated with general fetal development.
To analyze variations in sphenoid bone ossification.

Main Methods:

Analysis of roentgenograms from 145 human fetuses during the first half of prenatal development.
Categorization of ossification patterns based on observed centers (midsagittal vs. bilateral).
Division of the material into five distinct developmental stages for both maturation patterns.

Main Results:

Two distinct maturation patterns of the sphenoid bone were identified: a common midsagittal ossification center and a less common pattern with bilateral ossification centers.
These patterns were observed to persist throughout the investigated prenatal period.
The study successfully mapped ossification aspects within five developmental stages.

Conclusions:

The identified ossification patterns in the sphenoid bone are significant for normal cranial base development.
Recognizing these variations is essential for identifying and understanding deviations in cranial maturation and growth.
This research provides a foundation for further studies on cranial development anomalies.

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