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Angiotensin-(1-7) Mas-receptor deficiency decreases peroxisome proliferator-activated receptor gamma expression in

Erica Guilhen Mario1, Sérgio Henrique S Santos, Adaliene Versiane M Ferreira

  • 1Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Peptides
|November 29, 2011
PubMed

Insights

The angiotensin-(1-7)-Mas axis influences adipocyte metabolism and insulin response. Lack of this signaling pathway alters lipid profiles and impairs insulin action, potentially due to reduced PPARγ expression.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome Research
  • Cardiovascular Disease Etiology

Background:

  • The renin-angiotensin system links metabolic syndrome and cardiovascular diseases.
  • Angiotensin-(1-7), acting via the Mas receptor, has known cardiovascular effects.
  • The role of the angiotensin-(1-7)-Mas axis in lipid metabolism is not well understood.

Purpose of the Study:

  • To investigate the role of the angiotensin-(1-7)-Mas axis in adipocyte metabolism.
  • To determine the impact of Mas deficiency on lipid profiles and insulin sensitivity.

Main Methods:

  • Comparison of adipocyte metabolism in wild-type and Mas-deficient mice.
  • Analysis of gene expression for PPARγ, ACC, and FAS.
  • Measurement of serum nonesterified fatty acids and glycerol release.

Main Results:

  • Mas-knockout mice showed reduced expression of PPARγ, ACC, and FAS.
  • Serum nonesterified fatty acids were significantly increased in Mas-knockout mice.
  • Insulin's effect on glycerol release (lipolytic index) was impaired in Mas-knockout mice.

Conclusions:

  • The angiotensin-(1-7)-Mas axis is crucial for normal adipocyte response to insulin.
  • Mas deficiency alters lipid metabolism and insulin sensitivity, possibly via PPARγ downregulation.
  • This axis represents a potential therapeutic target for metabolic and cardiovascular diseases.

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