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Updated: May 27, 2026

Isolation of Brain-infiltrating Leukocytes

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Isolated neurosarcoidosis.

Bianca Szabo¹, Doiniţa Crişan, I Tompa

¹Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, Emergency County Hospital, Cluj-Napoca, Romania. bianca.szabo@gmail.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie

|November 29, 2011

Summary

This summary is machine-generated.

This case study highlights isolated neurosarcoidosis, a rare central nervous system manifestation of sarcoidosis. It emphasizes the importance of correlating MRI findings with clinical symptoms for accurate diagnosis and management of this complex inflammatory disease.

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Last Updated: May 27, 2026

Isolation of Brain-infiltrating Leukocytes

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Area of Science:

Neurology
Immunology
Pathology

Background:

Sarcoidosis is a multisystem inflammatory disease.
Neurosarcoidosis, affecting the central nervous system, occurs in ~25% of sarcoidosis patients, often subclinically.
Cranial nerve palsies and optic nerve involvement are common, portending poor visual prognosis.

Observation:

A patient presented with decreased visual acuity, facial hypoesthesia, and eyelid tumors.
Initial eyelid biopsy revealed non-caseating granulomas, suggesting sarcoidosis.
Two-year clinical and MRI follow-up confirmed isolated neurosarcoidosis via histology.

Findings:

MRI abnormalities correlated with presenting neurologic symptoms.
Imaging changes during follow-up reflected clinical worsening.
This case demonstrates characteristic neurosarcoidosis without systemic signs.

Implications:

Highlights the diagnostic challenges of isolated neurosarcoidosis.
Underscores the value of integrating clinical, imaging, and histological data.
Provides insights into the presentation and progression of neurosarcoidosis.