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Related Concept Videos

Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: May 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Epithelioid pituicytoma.

Jason A Ellis1, Nadejda M Tsankova, Randy D'Amico

  • 1Department of Neurological Surgery, Columbia University Medical Center, New York, New York, USA. jae2109@columbia.edu

World Neurosurgery
|November 29, 2011
PubMed
Summary
This summary is machine-generated.

Pituicytomas, rare sellar tumors, can present with an unusual epithelioid pattern, not just spindle cells. Thyroid transcription factor-1 (TTF-1) immunopositivity is key for diagnosing this rare variant.

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Published on: July 25, 2017

Area of Science:

  • Neuro-oncology
  • Endocrinology
  • Pathology

Background:

  • Pituicytomas are rare sellar region tumors originating from pituicytes.
  • Typically, they show spindle-cell morphology with fascicular or storiform growth patterns.
  • No histological variants were previously described.

Observation:

  • A diagnostically challenging case of pituicytoma in a 42-year-old male is presented.
  • The sellar mass arose from the pituitary stalk.
  • Histological examination revealed an epithelioid histoarchitecture, deviating from typical features.

Findings:

  • The tumor lacked characteristic spindle-cell or fascicular growth.
  • Strong immunopositivity for thyroid transcription factor-1 (TTF-1), a pituicyte marker, was observed.
  • This immunophenotype was crucial for diagnosis.

Implications:

  • Pituicytomas can exhibit epithelioid morphology, challenging traditional classification.
  • Diagnosis of epithelioid pituicytoma variants relies on clinical presentation and immunohistochemical analysis.
  • This finding expands the understanding of pituicytoma histopathology.