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Related Concept Videos

Knee Joint01:23

Knee Joint

The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.

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Related Experiment Video

Updated: May 27, 2026

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement
04:22

Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement

Published on: June 13, 2025

Somatosensory abnormalities in knee OA.

Vikki Wylde1, Shea Palmer, Ian D Learmonth

  • 1School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK. v.wylde@bristol.ac.uk

Rheumatology (Oxford, England)
|November 29, 2011
PubMed
Summary

Advanced knee osteoarthritis (OA) patients often exhibit somatosensory abnormalities, including tactile hypoaesthesia and pressure hyperalgesia, affecting both the knee and forearm.

Area of Science:

  • Neurology
  • Rheumatology
  • Pain Science

Background:

  • Osteoarthritis (OA) is a degenerative joint disease.
  • Somatosensory function alterations are increasingly recognized in OA.

Purpose of the Study:

  • To investigate the range and prevalence of somatosensory abnormalities in knee OA patients using quantitative sensory testing (QST).

Main Methods:

  • 107 knee OA patients and 50 healthy controls underwent QST at the knee and forearm.
  • Tested modalities included light-touch thresholds, pressure pain thresholds, and thermal sensation.
  • Statistical analyses identified differences and calculated the prevalence of abnormalities.

Main Results:

  • 70% of knee OA patients displayed at least one somatosensory abnormality.

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Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement
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Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
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Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

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  • Patients showed localized thermal and tactile hypoaesthesia and pressure hyperalgesia at the knee.
  • Tactile hypoaesthesia and pressure hyperalgesia were also found in the forearm.

    • Conclusions:

    • Knee OA is associated with diverse somatosensory abnormalities, notably tactile hypoaesthesia and pressure hyperalgesia.
    • These findings highlight the widespread sensory changes in OA patients.
    • Further research is warranted to understand the clinical significance of these abnormalities.