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Related Experiment Videos

Benign lymphangioendothelioma.

E W Jones1, R K Winkelmann, C B Zachary

  • 1Institute of Dermatology, St. John's Hospital for Diseases of the Skin, London, England.

Journal of the American Academy of Dermatology
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

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[Not Available].

Cylchgrawn Llyfrgell Genedlaethol Cymru. The National Library of Wales journal. National Library of Wales·2011

This study describes benign lymphangioendothelioma, a rare acquired lymphatic endothelial lesion presenting as skin macules and plaques. Surgical removal proved effective, with no recurrence observed in patients.

Area of Science:

  • Dermatopathology
  • Vascular Biology
  • Oncology

Background:

  • Acquired lymphatic endothelial lesions can present as benign skin manifestations.
  • Distinguishing these from other vascular tumors is crucial for accurate diagnosis and treatment.

Observation:

  • Eight cases of a novel acquired lymphatic endothelial lesion were studied.
  • Lesions appeared as solitary, slow-growing, erythematous macules/plaques on extremities/shoulders in adolescents/adults.
  • Histopathology revealed dermal collagen permeation by endothelium-lined channels, negative for hemorrhage, iron, or inflammation.

Findings:

  • Immunohistochemistry showed consistent Ulex europaeus agglutinin I labeling and negative factor VIII-related antigen.
  • These findings support a lymphatic endothelial origin for the lesion.

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  • Surgical excision in six patients resulted in no recurrence.

    • Implications:

    • The proposed name 'benign lymphangioendothelioma' accurately reflects the lesion's nature and behavior.
    • This condition represents a distinct clinicopathologic entity within the spectrum of vascular anomalies.
    • Benign lymphangioendothelioma is amenable to surgical treatment with a favorable prognosis.