Related Experiment Video
Updated: May 27, 2026
08:30
A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
Published on: September 16, 2022
Acute bacterial skin and skin structure infections: current perspective
1Medical College, Vadodara, Gujarat, India.
Indian Journal of Dermatology
|November 29, 2011
Summary
Acute bacterial skin and skin structure infections (ABSSSI) are common and challenging due to rising antimicrobial resistance. Ceftaroline shows promise as a new agent to combat these resistant bacterial infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Acute bacterial skin and skin structure infections (ABSSSI) represent a significant clinical challenge.
- Treatment is complicated by increasing antimicrobial resistance, particularly from Gram-positive bacteria like methicillin-resistant Staphylococcus aureus (MRSA).
Purpose of the Study:
- To highlight the growing problem of antimicrobial resistance in ABSSSI.
- To introduce ceftaroline as a potential therapeutic agent against resistant bacterial pathogens.
Main Methods:
- Literature review on ABSSSI epidemiology and resistance patterns.
- Review of pharmacological data for ceftaroline efficacy.
Main Results:
- Antimicrobial resistance is a primary concern in managing ABSSSI.
- Ceftaroline demonstrates potential as a novel therapeutic option.
Conclusions:
- There is an urgent need for new antimicrobial agents to treat ABSSSI.
- Ceftaroline is a promising cephalosporin for addressing resistant bacterial infections.
Related Concept Videos
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:27The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:25Urinary Tract Infection II: Pathophysiology
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...