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Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
Published on: March 29, 2017
Lipid chaperones and metabolic inflammation
Masato Furuhashi1, Shutaro Ishimura, Hideki Ota
1Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan.
International Journal of Inflammation
|November 29, 2011
Summary
Obesity and diabetes involve chronic inflammation, termed "metaflammation," driven by metabolic pathways. Fatty acid-binding proteins (FABPs) are key players in this inflammation, impacting diseases like atherosclerosis.
Area of Science:
- Metabolic and immune system interactions
- Cellular and molecular biology
- Pathophysiology of metabolic diseases
Background:
- Obesity and associated disorders (insulin resistance, type 2 diabetes) are linked to chronic, low-grade inflammation known as "metaflammation."
- Metaflammation is triggered by inflammatory cytokines, lipids, and metabolic stress pathways, affecting critical organs like adipocytes and macrophages.
- Cellular components including fatty acid-binding proteins (FABPs), endoplasmic reticulum (ER) stress, and mitochondrial reactive oxygen species (ROS) contribute to metabolic inflammation.
Purpose of the Study:
- To elucidate the molecular and cellular mechanisms underlying the role of FABPs in metaflammation.
- To discuss the involvement of FABP4 and FABP5 in the development of obesity, type 2 diabetes, and atherosclerosis.
Main Methods:
- Review of existing evidence on metabolic and immune pathway integration.
- Analysis of the role of cellular stress pathways in inflammation.
- Focus on the function of specific fatty acid-binding proteins (FABP4, FABP5).
Main Results:
- Evidence confirms the integration of metabolic and immune responses.
- Metaflammation is a key feature of obesity and related metabolic disorders.
- FABPs, particularly FABP4 and FABP5, are implicated as significant mediators of metabolically triggered inflammation.
Conclusions:
- FABPs play a crucial role in the pathogenesis of metaflammation.
- Understanding FABP function is vital for developing therapeutic strategies for obesity, diabetes, and atherosclerosis.
- Targeting FABPs may offer a novel approach to managing these metabolic diseases.
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