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Dermatoses associated with sterile lytic bone lesions.

M S Sofman1, N S Prose

  • 1Department of Dermatology, State University of New York, Health Science Center, Brooklyn.

Journal of the American Academy of Dermatology
|September 1, 1990
PubMed
Summary

Several skin conditions, including palmoplantar pustulosis and acne fulminans, are linked to sterile bone lesions. This review explores their clinical, lab, and histologic features, suggesting a shared cause for the bone damage.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Recent research links specific dermatoses to sterile lytic bone lesions.
  • Palmoplantar pustulosis, acne fulminans, and Sweet's syndrome are among these associated conditions.
  • Understanding the connection between these skin disorders and bone pathology is crucial.

Purpose of the Study:

  • To review the clinical, laboratory, and histologic findings of dermatoses associated with sterile lytic bone lesions.
  • To explore a potential common pathogenic mechanism for these bone lesions.
  • To consolidate current knowledge on this interdisciplinary medical phenomenon.

Main Methods:

  • Literature review of clinical case studies and research articles.
  • Analysis of diagnostic criteria for the mentioned dermatoses.

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  • Histopathological examination review of bone lesions.

    • Main Results:

    • Consistent association between palmoplantar pustulosis, acne fulminans, Sweet's syndrome, and sterile lytic bone lesions.
    • Identification of shared clinical and histological features across these conditions.
    • Evidence supporting a common inflammatory or immune-mediated pathway.

    Conclusions:

    • A unifying pathogenic mechanism is likely involved in the bone lesions of these dermatoses.
    • Further research is warranted to elucidate the precise molecular and cellular pathways.
    • This understanding may lead to targeted therapeutic strategies for bone complications.