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Updated: May 27, 2026
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A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
Published on: November 8, 2014
[Research progress of zebrafish used in drug metabolism]
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|November 30, 2011
Abstract:
Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.
