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Published on: November 18, 2022
[Protective effects and mechanism of hyperin on CoCl2-induced PC12 cells]
Kewu Zeng1, Xuemei Wang, Hong Fu
1Research Studio of Integration of Traditional and Western Medicine, First Hospital, Peking University, Beijing 100034, China.
Objective:
To investigate the neuroprotective effects and mechanism of hyperin on CoCl2-induced hypoxic/ischemic PC12 cells.
Method:
CoCl2 was used to treat rat pheochromocytoma cell line (PC12) to investigate the protective effects of different concentrations of hyperin.
Result:
Hyperin could significantly inhibit CoCl2-induced cytotoxicity and apoptosis on PC12 cells in a dose-dependent manner, by inhibiting reactive oxygen species (ROS) production, increasing mitochondrial membrane potential (MMP), and inactivating caspase-3 and poly ADP-ribose polymerase (PARP).
Conclusion:
Hyperin could inhibit CoCl2-induced cytotoxicity and apoptosis on PC12 cells, show neuroprotective effects on hypoxic/ischemic neural injuries.
