Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Gene-Environment Interactions

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

Background and Environment Affect Phenotype

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Main Outcomes of the HEBE Trial: Improving Cardiorespiratory Fitness and Body Composition Through a Tailored Feasible Lifestyle Program.

Nutrients·2026

Same author

Exposure to coal-fired power plant emissions, unconventional natural gas development, and salivary miRNA profiles and asthma in children.

Environmental research·2026

Same author

Leveraging Artificial Intelligence in Allergy, Asthma, and Immunology With Environmental Exposures.

Allergy·2026

Same author

An Apple a Day? The Hypothesis of Cross-Kingdom Gene Regulation by Plant miRNAs in Mammals and Its Controversies.

International journal of molecular sciences·2026

Same author

Application of integrated nested Laplace approximation to identify hot spots of methylation heterogeneity in healthy individuals from the MAMELI cohort.

Frontiers in genetics·2026

Same author

Blood mitochondrial heteroplasmic variants and cognitive performance in late midlife: REGARDS study.

BMC neurology·2026

Search research articles

Related Experiment Video

Updated: May 27, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Epigenetics and lifestyle.

Jorge Alejandro Alegría-Torres¹, Andrea Baccarelli, Valentina Bollati

¹Departamento de Toxicologia Ambiental, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Mexico.

|November 30, 2011

Summary

This summary is machine-generated.

Lifestyle choices like diet and exercise impact health through epigenetic changes. This review explores how factors such as nutrition and stress modify DNA methylation, histone acetylation, and miRNA expression, influencing overall well-being.

More Related Videos

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Related Experiment Videos

Last Updated: May 27, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

Area of Science:

Epigenetics
Molecular Biology
Public Health

Background:

Lifestyle encompasses diverse factors including nutrition, physical activity, stress, and substance use.
Emerging evidence links environmental and lifestyle factors to epigenetic modifications.
Epigenetic mechanisms include DNA methylation, histone acetylation, and microRNA (miRNA) expression.

Purpose of the Study:

To review current evidence on the influence of lifestyle factors on epigenetic mechanisms.
To highlight the role of lifestyle in modulating epigenetic patterns relevant to human health.

Main Methods:

Literature review of studies investigating lifestyle factors and epigenetic modifications.
Focus on DNA methylation, histone modifications, and miRNA expression.

Main Results:

Several lifestyle factors (diet, obesity, physical activity, smoking, alcohol, pollutants, stress, night shifts) are associated with altered epigenetic patterns.
Most research has focused on DNA methylation, with fewer studies on histone modifications and miRNAs.
Lifestyle-induced epigenetic changes are proposed mechanisms linking lifestyle to human health outcomes.

Conclusions:

Lifestyle factors significantly influence epigenetic mechanisms.
Epigenetic modifications represent a key pathway through which lifestyle impacts human health.
Further research is needed, particularly on histone modifications and miRNAs in relation to lifestyle.