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Immunogold Electron Microscopy

Immunogold Electron Microscopy

Immunoelectron microscopy utilizes immunogold labeling of endogenous proteins with specific antibodies to detect and localize these proteins in cells and tissues. The procedure provides insights into the distribution and quantification of protein under different stimulation conditions offering clues about their functions. Conjugating highly electron-dense gold particles with primary or secondary antibodies allow antigen detection on and within cells, with high resolution and specificity.

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

Reporter Genes

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Related Experiment Video

Updated: May 27, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy

Published on: May 16, 2022

Gold nanoprobes for theranostics.

Balaji Panchapakesan¹, Brittany Book-Newell, Palaniappan Sethu

¹Department of Mechanical Engineering, Small Systems Laboratory, University of Louisville, Louisville, KY 40292, USA.

Nanomedicine (London, England)

|November 30, 2011

Summary

This summary is machine-generated.

Gold nanoprobes offer precise synthesis and versatile properties for advanced medical diagnostics and therapies. This review explores their exciting potential in theranostics for improved patient outcomes.

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Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Gold nanoprobes are increasingly utilized in medicine and life sciences.
Their atomic-level precision synthesis and unique properties make them highly valuable.

Purpose of the Study:

To review recent advancements in gold nanoprobes.
To highlight their potential applications in theranostics.

Main Methods:

Literature review of recent studies on gold nanoprobes.
Analysis of their properties and applications in theranostics.

Main Results:

Gold nanoprobes exhibit reproducible synthesis and tunable properties.
They offer versatility in morphology, functionalization, and targeting.
Potential for efficient drug delivery and multimodal therapy.

Conclusions:

Gold nanoprobes show significant promise for theranostic applications.
Further research can unlock their full potential in personalized medicine.