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Updated: May 27, 2026

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

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Published on: May 28, 2021

Decrease in interleukin-21 in children suffering with severe atopic dermatitis.

Sheng-Chieh Lin1, Ya-Hui Chuang, Yao-Hsu Yang

  • 1Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|November 30, 2011
PubMed
Summary
This summary is machine-generated.

Interleukin-21 (IL-21) levels are decreased in children with severe atopic dermatitis (AD), indicating a potential role for this cytokine in AD pathogenesis. This study investigated IL-21 expression in AD patients.

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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
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06:38

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Published on: August 4, 2022

Area of Science:

  • Immunology
  • Dermatology
  • Cytokine Research

Background:

  • Atopic dermatitis (AD) is an inflammatory skin condition linked to T helper type 2 (Th2) cells and cytokines like IL-4 and IL-5.
  • Interleukin-21 (IL-21), a cytokine primarily from activated CD4+ T cells, has not been clinically studied in AD patients.
  • Understanding cytokine roles is crucial for developing targeted AD therapies.

Purpose of the Study:

  • To investigate the clinical significance of Interleukin-21 (IL-21) in patients with atopic dermatitis (AD).
  • To analyze serum levels of various cytokines, including IL-21, in AD cases and healthy controls.
  • To explore correlations between IL-21 levels and clinical disease severity.

Main Methods:

  • Serum levels of total IgE, specific IgE, and cytokines (IL-4, IL-5, IFN-γ, IL-17, IL-21) were measured in AD patients and controls.
  • Cytokine production was assessed in peripheral blood mononuclear cells stimulated in vitro.
  • Clinical severity was evaluated using the Scoring of Atopic Dermatitis (SCORAD) index.

Main Results:

  • Serum total IgE was significantly higher in AD patients compared to controls.
  • Serum IL-21 and IFN-γ levels showed a significant positive correlation.
  • No significant correlation was found between IL-21 and IL-4, IL-5, or IL-17 levels.

Conclusions:

  • A significant decrease in IL-21 levels was observed in children with severe AD.
  • These findings suggest that IL-21 may play a role in the immunopathogenesis of atopic dermatitis.
  • Further research is warranted to elucidate the precise function of IL-21 in AD.