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Coronary ectasia is associated with impaired left ventricular myocardial performance in patients without significant

Koksal Ceyhan1, Fatih Koc, Kurtulus Ozdemir

  • 1Department of Cardiology, School of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|November 30, 2011
PubMed

Insights

Coronary artery ectasia (CAE) is associated with altered left ventricular function, as indicated by increased myocardial performance index (MPI) measured by tissue Doppler echocardiography. Right ventricular function remains unaffected in patients with CAE.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Physiology

Background:

  • Coronary artery ectasia (CAE) is a non-obstructive coronary artery disease.
  • Ventricular function assessment is crucial in cardiovascular disease management.
  • Tissue Doppler echocardiography (TDE) provides valuable insights into myocardial performance.

Purpose of the Study:

  • To evaluate left and right ventricular functions in patients with CAE.
  • To assess the myocardial performance index (MPI) using TDE in CAE patients.
  • To compare ventricular functions and MPI between CAE patients and healthy controls.

Main Methods:

  • A case-control study involving 25 patients with CAE and 25 age/sex-matched controls.
  • Conventional echocardiography and TDE were used to assess ventricular functions.
  • Myocardial performance index (MPI) was calculated for both ventricles.

Main Results:

  • Left ventricular MPI was significantly increased in CAE patients compared to controls (p < 0.05).
  • Specific increases were noted in the left ventricle-lateral wall and interventricular septum MPI.
  • Right ventricular MPI showed no significant difference between CAE patients and controls (p > 0.05).

Conclusions:

  • Left ventricular MPI is significantly altered in patients with CAE, even without obstructive coronary artery disease.
  • Right ventricular MPI remains comparable between CAE patients and the control group.
  • TDE-derived MPI can detect subtle left ventricular dysfunction in CAE.
Abstract

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