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Updated: May 27, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
The insulin-like growth factor system in kidney disease and hypertension
1Department of Endocrinology and Diabetes, The Alfred, Melbourne, Australia. leon.bach@monash.edu
Purpose Of Review:
The insulin-like growth factor system plays an important role in renal physiology and it is perturbed in a range of kidney diseases.
Recent Findings:
Some insulin-like growth factor (IGF) actions in the kidney are mediated by nitric oxide. Growth hormone and IGF-binding proteins may contribute to renal diseases via effects on podocytes and proximal tubule cells. In contrast, growth hormone and IGF-I may counteract the catabolic consequences of end-stage renal disease. Polymorphisms in the IGF system are associated with hypertension.
Summary:
Further studies are needed to determine whether modulating the IGF system may have a role in treating kidney diseases and/or hypertension.
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