Related Experiment Video
Updated: May 27, 2026
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell carcinoma
Jue Wang1, Geoffrey A Talmon, Michael Feloney
1Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7680, USA. juewang@unmc.edu
Background:
Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy.
Patients And Methods:
We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patient subsequently had multiple tumor recurrences.
Results:
The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis.
Conclusion:
Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.
