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The daylong pattern of the antianginal effect of long-term three times daily administered isosorbide dinitrate

M M Bassan1

  • 1Jerusalem Heart Clinic of Kupat Holim, Israel.

Journal of the American College of Cardiology
|October 1, 1990
PubMed

Insights

Three times daily isosorbide dinitrate provides a daylong antianginal effect, though tolerance may develop. This dosing schedule helps manage exertional angina by improving exercise duration.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Isosorbide dinitrate is a common antianginal medication.
  • Tolerance to isosorbide dinitrate can limit its effectiveness with frequent dosing.

Purpose of the Study:

  • To investigate the daylong pattern of antianginal effects of three times daily isosorbide dinitrate.
  • To assess the efficacy of this dosing regimen in patients with stable exertional angina.

Main Methods:

  • Eight men with stable exertional angina participated.
  • A double-blind, placebo-controlled study was conducted.
  • Treadmill exercise tests were performed at various times after medication or placebo administration.

Main Results:

  • The 8 AM dose of isosorbide dinitrate increased exercise duration by 200 seconds, but effects diminished by 11 AM.
  • The 1 PM dose also increased exercise duration, with effects returning to baseline within 2 hours.
  • A trend towards diminished response was observed throughout the day.

Conclusions:

  • Three times daily isosorbide dinitrate demonstrates a daylong antianginal effect.
  • Tolerance to isosorbide dinitrate may develop, impacting its sustained efficacy throughout the day.

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