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Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

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Updated: May 27, 2026

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Non-human primate dendritic cells.

Shilpanjali Jesudason¹, Michael G Collins, Natasha M Rogers

¹Transplantation Immunology Laboratory and Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital Campus, Adelaide, South Australia, Australia.

Journal of Leukocyte Biology

|November 30, 2011

Summary

This summary is machine-generated.

Non-human primate dendritic cells (DC) are crucial for research, but their unique characteristics differ from human DC. Understanding these differences is vital for developing effective DC-based therapies in preclinical models.

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Last Updated: May 27, 2026

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Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

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Published on: April 18, 2016

Area of Science:

Immunology
Translational Medicine
Primate Research

Background:

Non-human primates (NHP) serve as critical translational models in biomedical research.
Dendritic cells (DC), a type of antigen-presenting cell (APC), are key players in immune responses and immunotherapy.
DC have been extensively studied in humans and mice, but their characterization in NHP is recent.

Purpose of the Study:

To review and summarize the current understanding of dendritic cells (DC) in non-human primates (NHP).
To compare the characteristics of NHP DC with those of human DC.
To highlight the implications of NHP DC differences for translational research.

Main Methods:

Literature review of available data on DC in various NHP species.
Summary of findings on both in vitro-propagated and in vivo-isolated DC.
Comparative analysis of NHP DC phenotypes and functions against human DC subsets.

Main Results:

Dendritic cells (DC) in NHP share a general paradigm with human DC.
Significant functional and phenotypic differences exist between NHP DC subsets and human DC subsets.
Current understanding of NHP DC is now established through available data.

Conclusions:

NHP are valuable models for studying dendritic cells (DC) and developing DC-based therapies.
Acknowledging the distinct functional and phenotypic profiles of NHP DC is essential.
These differences must be considered when designing preclinical translational studies utilizing NHP models for DC therapy.