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Related Concept Videos

Complexometric Titration: Overview00:39

Complexometric Titration: Overview

Complexometric titration involves the formation of a complex by reacting a metal ion with one or more ligands. A visual indicator often detects the end point of a complexometric titration. It is added to the metal solution before the titration, forming a stable metal–indicator complex and imparting color to the solution. As the titration approaches the equivalence point, the excess of the added ligand displaces the indicator from the metal–indicator complex, releasing the free indicator. The...
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
Electrodeposition01:08

Electrodeposition

Electrodeposition is a technique used to separate an analyte from interferents by electrochemical processes. Here, the analyte is a metal ion that can be deposited on an electrode immersed in the sample solution. The electrochemical setup consists of an anode and a cathode. When an electric current is applied to the setup, oxidation occurs at the anode. At the cathode, which consists of a large metal surface, metal ions undergo reduction and deposit onto the surface.
Electrodeposition can...
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
Voltammetry: Stripping Methods01:13

Voltammetry: Stripping Methods

Anodic Stripping Voltammetry (ASV), Cathodic Stripping Voltammetry (CSV), and Adsorptive Stripping Voltammetry (AdSV) are electrochemical techniques used to determine trace amounts of analytes in solution. These methods involve applying a potential to an electrode and measuring the resulting current.
Anodic Stripping Voltammetry (ASV)
ASV is used to determine metals and metalloids at trace levels. It involves two steps: deposition and stripping. First, a negative potential is applied to the...

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Updated: May 27, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
11:56

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

A novel dinuclear Schiff-base copper(II) complex modified electrode for ascorbic acid catalytic oxidation and

Zhijun Zhang1, Xi Li, Chenggang Wang

  • 1Department of Chemistry, School of Science, Wuhan University of Technology, Wuhan, 430070, PR China.

Dalton Transactions (Cambridge, England : 2003)
|November 30, 2011
PubMed
Summary

A novel dinuclear copper complex was synthesized and used to modify a glass carbon electrode. This modified electrode shows excellent electrocatalytic activity for ascorbic acid detection, enabling vitamin C tablet analysis.

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Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks
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Accumulation and Analysis of Cuprous Ions in a Copper Sulfate Plating Solution
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Accumulation and Analysis of Cuprous Ions in a Copper Sulfate Plating Solution

Published on: March 20, 2019

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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Published on: April 11, 2014

Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks
06:53

Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks

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Accumulation and Analysis of Cuprous Ions in a Copper Sulfate Plating Solution
07:00

Accumulation and Analysis of Cuprous Ions in a Copper Sulfate Plating Solution

Published on: March 20, 2019

Area of Science:

  • Coordination Chemistry
  • Electrochemistry
  • Materials Science

Background:

  • Schiff-base complexes are versatile ligands in coordination chemistry.
  • Copper complexes exhibit diverse electrochemical and catalytic properties.
  • Electropolymerization offers a route to create modified electrode surfaces.

Purpose of the Study:

  • To synthesize and characterize a novel dinuclear copper salicylaldehyde-glycine Schiff-base complex.
  • To investigate the electropolymerization behavior of the copper complex on a glass carbon electrode.
  • To evaluate the electrocatalytic performance of the modified electrode for ascorbic acid determination.

Main Methods:

  • Synthesis and single-crystal X-ray diffraction of the dinuclear copper complex.
  • Electropolymerization studies on a glass carbon electrode at varying potential ranges.
  • Amperometric determination of ascorbic acid using the modified electrode.

Main Results:

  • The dinuclear copper complex [Cu(2)(Sal-Gly)(2)(H(2)O)(2)] was successfully synthesized and structurally characterized, crystallizing in the monoclinic P2(1)/c space group.
  • Electropolymerization of the complex occurred at a high scan potential of 1.4 V, forming a stable modified electrode.
  • The modified electrode demonstrated significant electrocatalytic oxidation of ascorbic acid with high sensitivity (22.9 nA μM⁻¹) and a low detection limit (0.39 μM).

Conclusions:

  • A novel dinuclear copper Schiff-base complex was synthesized and characterized.
  • The complex can be electropolymerized to form a modified electrode with excellent electrocatalytic properties.
  • The developed method is suitable for the sensitive and accurate determination of ascorbic acid in vitamin C tablets.