Vascular reactivity in human arteries: from experimental study to clinical application

The principal function of VSM cells in mature animals is contraction. The endothelium is now recognized to elaborate various vasoactive factors and to play a critical part in regulation of vascular tone. Many circulating mediators and hormones have effects on vascular tone that are mediated via multiple receptors. Vasoactive agents also exert their effects on tissues by acting on one or more processes in the contraction–relaxation cycle in VSM. In humans,systemic, pulmonary, and various organ circulation(s) are maintained by an intricate and complex cardiovascular system. We expect future studies to clarify the sophisticated but complex mechanisms of VSM in humans.