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Updated: May 27, 2026
08:53
Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model
Published on: January 1, 2017
[Strontium ranelate in post-menopausal osteoporosis]
1Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych, Warszawski Uniwersytet Medyczny, Warszawa. jprzedlacki@amwaw.edu.pl
Endokrynologia Polska
|November 30, 2011
Summary
Strontium ranelate is a first-line osteoporosis treatment that uniquely stimulates bone formation and resorption. It effectively prevents fractures, particularly in post-menopausal women, and improves bone mineral density.
Area of Science:
- Pharmacology
- Bone Biology
- Endocrinology
Context:
- Osteoporosis is a significant health concern, especially in post-menopausal women.
- Current treatments aim to reduce fracture risk through various mechanisms.
- Strontium ranelate offers a unique dual action on bone metabolism.
Purpose:
- To review the therapeutic indications, efficacy, and safety of strontium ranelate.
- To elucidate the mechanism of action of strontium ranelate in osteoporosis.
- To compare strontium ranelate's anti-fracture efficacy with other osteoporosis agents.
Summary:
- Strontium ranelate is a first-line agent for post-menopausal osteoporosis with proven anti-fracture activity.
- It uniquely stimulates both bone formation and resorption via calcium receptors and the OPG/RANKL system.
- The drug effectively prevents spinal, hip, and extravertebral fractures, with efficacy independent of age or baseline BMD for spinal fractures.
Impact:
- Strontium ranelate increases bone mineral density and modulates bone turnover markers.
- Its efficacy in hip fracture prevention is noted in women at increased risk.
- This review provides comprehensive information on strontium ranelate's clinical use, side effects, and contraindications.
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