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Telmisartan versus valsartan in patients with hypertension: effects on cardiovascular, metabolic, and inflammatory

Sung Yoon Lim1, Sun Won Kim, Eung Ju Kim

  • 1Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Korean Circulation Journal
|November 30, 2011
PubMed

Insights

Telmisartan and valsartan, both angiotensin-receptor blockers (ARBs), showed similar effects on cardiovascular, metabolic, and inflammatory markers in patients with hypertension over 12 weeks.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Background:

  • Angiotensin-receptor blockers (ARBs) offer cardiovascular, metabolic, and inflammatory benefits beyond blood pressure control.
  • Comparative studies on different ARBs are limited.
  • This study investigated telmisartan versus valsartan in uncomplicated hypertension.

Purpose of the Study:

  • To compare the effects of telmisartan and valsartan on cardiovascular, metabolic, and inflammatory parameters.
  • To evaluate changes in vascular and echocardiographic data.
  • To assess treatment efficacy in patients with essential hypertension.

Main Methods:

  • Randomized trial with 60 patients with essential hypertension.
  • 12-week treatment with telmisartan (80 mg/day) or valsartan (160 mg/day).
  • Measurements included anthropometric, laboratory, vascular (cfPWV), and echocardiographic (LVMI) data.

Main Results:

  • Both telmisartan and valsartan significantly reduced blood pressure.
  • Carotid-femoral pulse wave velocity (cfPWV) and left ventricular mass index (LVMI) showed significant reductions with telmisartan, but differences between groups were not significant after adjustment.
  • No significant changes in other vascular, metabolic, or inflammatory parameters were observed.

Conclusions:

  • A 12-week treatment with telmisartan and valsartan yielded comparable effects on cardiovascular, metabolic, and inflammatory parameters.
  • Neither ARB demonstrated superiority in the studied parameters for uncomplicated hypertension.
  • The findings suggest similar therapeutic profiles for telmisartan and valsartan in this patient group.
Abstract

Keywords:
HypertensionValsartan

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