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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
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Default-mode-like network activation in awake rodents.

Jaymin Upadhyay1, Scott J Baker, Prasant Chandran

  • 1Translational Sciences, Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, United States of America. jaymin.upadhyay@abbott.com

Plos One
|November 30, 2011
PubMed
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Researchers found that awake rodents exhibit default-mode network (DMN) functional connectivity after habituation to MRI scanning. This DMN-like network emerged as anxiety-related brain connectivity decreased, highlighting the cingulate cortex

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Comparative Neuroscience

Background:

  • The default-mode network (DMN) is an intrinsic brain network active during wakeful rest in humans and primates.
  • DMN activity patterns are altered in various neurological and psychiatric conditions.
  • The existence and characteristics of a DMN in awake rodents remained uninvestigated.

Purpose of the Study:

  • To determine if awake rodents possess a DMN-like functional connectivity.
  • To characterize the emergence of DMN-like connectivity in rodents during habituation to an MRI environment.
  • To explore the relationship between DMN-like and anxiety-related networks in rodents.

Main Methods:

  • Utilized functional magnetic resonance imaging (fMRI) in awake rodents over multiple scanning sessions (Days 2, 4, 6, 8) to assess brain network connectivity.

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  • Employed seed-based correlation analysis focusing on the anterior cingulate cortex.
  • Analyzed functional connectivity patterns associated with DMN and anxiety-related brain structures.

    • Main Results:

    • Awake rodents demonstrated significant DMN-like functional connectivity (anterior cingulate, retrosplenial, parietal, hippocampal cortices) by Day 8 of habituation.
    • Prior to habituation (Day 2), functional connectivity was primarily observed in anxiety-mediating structures (anterior cingulate, posterior hypothalamic area, amygdala, parabracial nucleus).
    • A significant inverse relationship was found between cingulate-DMN and cingulate-anxiety network connectivity across habituation days.

    Conclusions:

    • Awake rodents exhibit a DMN-like functional network that emerges with habituation to the MRI environment.
    • The cingulate cortex plays a crucial role in both the rodent DMN-like and anxiety networks.
    • Habituation is essential for revealing DMN-like connectivity in rodents, suggesting environmental factors influence intrinsic brain networks.