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The prevalence of congenital malformations and its correlation with consanguineous marriages

Naeimeh Tayebi, Katayon Yazdani, Nazila Naghshin

    Oman Medical Journal
    |November 30, 2011
    PubMed

    Insights

    Consanguineous marriages in Iran significantly increase the risk of congenital anomalies in newborns. This study highlights the impact of family marriages on infant health outcomes.

    Area of Science:

    • Medical Genetics
    • Public Health
    • Reproductive Health

    Background:

    • Consanguinity, a common practice in some Iranian societies, has been historically linked to genetic disorders.
    • Understanding the specific impact of consanguineous marriages on congenital malformations is crucial for public health initiatives.

    Purpose of the Study:

    • To investigate the association between consanguinity and the occurrence of congenital anomalies in newborns.
    • To determine the correlation between the inbreeding coefficient and the prevalence of birth defects.

    Main Methods:

    • A cross-sectional study was conducted on 1195 newborns at Shahid Sadoughi hospital, Yazd, Iran.
    • Data collection spanned a 9-month period from April to December 2008.
    • Newborns were categorized based on parental marriage type (consanguineous vs. non-consanguineous).

    Main Results:

    • Out of 1195 neonates, 300 (25%) were born to consanguineous parents, while 895 (75%) were from non-familial marriages.
    • Congenital anomalies were observed in 34 (2.8%) neonates from consanguineous marriages and 11 (0.9%) from non-familial marriages.
    • A statistically significant correlation (p=0.018) was found between parental consanguinity and the prevalence of congenital anomalies.

    Conclusions:

    • The prevalence of congenital anomalies is significantly higher in newborns from consanguineous marriages compared to those from non-consanguineous unions.
    • Consanguinity plays a notable role in the occurrence of birth defects within the studied Iranian population.
    Abstract

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