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Related Experiment Video

Updated: May 27, 2026

Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Modification of microneedles using inkjet printing.

R D Boehm, P R Miller, S L Hayes

    AIP Advances
    |November 30, 2011
    PubMed
    Summary

    Biodegradable microneedles containing quantum dots were created using advanced 3D printing and inkjet methods. This technique allows for versatile fabrication of microneedles for drug delivery applications.

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    Area of Science:

    • Biomaterials Science
    • Nanotechnology
    • Drug Delivery Systems

    Background:

    • Microneedle technology offers a minimally invasive approach for transdermal drug delivery.
    • Biodegradable polymers are crucial for developing safe and effective microneedle patches.
    • Quantum dots provide unique imaging capabilities for tracking microneedle distribution.

    Purpose of the Study:

    • To fabricate biodegradable acid anhydride copolymer microneedles incorporating quantum dots.
    • To evaluate the mechanical properties of the developed microneedles.
    • To demonstrate the imaging of quantum dots within biological tissue using the fabricated microneedles.

    Main Methods:

    • Fabrication of microneedles using visible light dynamic mask micro-stereolithography-micromolding and inkjet printing.
    • Nanoindentation for assessing hardness and Young's modulus of the copolymer.
    • Multiphoton microscopy for imaging quantum dots within porcine skin.

    Main Results:

    • Successful fabrication of solid biodegradable microneedles with tunable geometries.
    • Quantification of mechanical properties (hardness and Young's modulus) of the copolymer.
    • Demonstration of quantum dot imaging within porcine skin, confirming microneedle presence and distribution.

    Conclusions:

    • The combined micro-stereolithography-micromolding and inkjet printing technique is effective for creating versatile biodegradable microneedles.
    • These quantum dot-loaded microneedles show potential for advanced drug delivery and in-situ monitoring.
    • The developed fabrication method supports a wide range of microneedle geometries and drug compositions.

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    Last Updated: May 27, 2026

    Polymeric Microneedle Array Fabrication by Photolithography
    08:15

    Polymeric Microneedle Array Fabrication by Photolithography

    Published on: November 17, 2015

    Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
    06:25

    Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

    Published on: December 5, 2025