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Updated: May 27, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
[Expression and clinical significance of FOX04 in colorectal cancer]
Liu Xiang-qiang1, Tang Shan-hong, Zhang Zhi-yong
1Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
Aim:
To investigate the expression and clinical significance of FOXO4 in colorectal cancer tissues.
Methods:
Immunohistochemistry assay was performed to detect the FOXO4 expression in 80 colorectal cancer and matched noncancerous tissues (18 cases in stage I, 32 in stage II, 24 in stage III and 6 in stage IV). The relationship between FOXO4 expression and the patients' clinicopathologic features including gender, differentiation and TNM staging was also analyzed.
Results:
The positive expression rate of FOXO4 protein in colorectal cancer tissues was 47.50%, which was significantly lower than that in matched noncancerous tissues (91.25%, P
Conclusion:
The expression of FOXO4 was significantly decreased or deleted in colorectal cancer, indicating that FOXO4 may function as a tumor suppressor in the development and progression of colorectal cancer.
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