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Cephalometric evaluation of children with familial Mediterranean fever

Ahmet Yalcin Gungor1, Vefik Arica, Ozge Gungor

  • 1Department of Orthodontics, Faculty of Dentistry, University of Akdeniz, Antalya, Turkey.

The Angle Orthodontist
|December 1, 2011
PubMed
Abstract

Insights

Familial Mediterranean fever (FMF) significantly alters craniofacial morphology, with FMF patients exhibiting shorter facial heights and mandibular lengths compared to healthy individuals. These findings reject the null hypothesis of no morphological differences.

Area of Science:

  • Orthodontics
  • Genetics
  • Pediatric Dentistry

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
  • Craniofacial morphology can be influenced by systemic conditions.

Purpose of the Study:

  • To compare craniofacial morphology between FMF patients and healthy controls.
  • To test the hypothesis that no morphological differences exist.

Main Methods:

  • Lateral cephalograms of 32 FMF patients and 32 controls were analyzed.
  • Cranial and dentofacial parameters were measured using cephalometric software.
  • Independent t-tests were used for statistical comparison.

Main Results:

  • FMF patients showed significantly greater ANB angle.
  • Anterior and posterior face heights were significantly shorter in FMF patients.
  • Mandibular length and upper incisor protrusion differed significantly.

Conclusions:

  • The null hypothesis was rejected, indicating significant craniofacial differences.
  • FMF is associated with distinct craniofacial morphology.
  • Further research into the clinical implications is warranted.

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