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Correlation between different genotypes of human cytomegalovirus and Epstein-Barr virus and peri-implant tissue
S Jankovic1, Z Aleksic, B Dimitrijevic
1Department of Periodontics, School of Dentistry, University of Belgrade, Belgrade, Serbia. drsashaj@gmail.com
Background:
The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters.
Methods:
A total of 80 dental implants (mean time of loading, 4.16 ± 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples.
Results:
HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis.
Conclusions:
The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.
Insights
Human cytomegalovirus (HCMV) genotype 2 and Epstein-Barr virus (EBV) genotype 1 are highly prevalent in peri-implantitis. Their presence correlates with clinical signs, suggesting a role in disease development.
Area of Science:
- Oral microbiology
- Virology
- Periodontology
Background:
- Peri-implantitis and mucositis are common complications of dental implants.
- The role of herpesviruses, such as HCMV and EBV, in these conditions is not fully understood.
Purpose of the Study:
- To determine the prevalence of HCMV and EBV genotypes in peri-implantitis and mucositis.
- To investigate the association between herpesvirus genotypes and clinical indicators of peri-implant disease.
Main Methods:
- 80 dental implants were assessed, including sites with peri-implantitis, mucositis, and healthy tissue.
- Clinical parameters like plaque index, bleeding, suppuration, and probing depth were recorded.
- Polymerase chain reaction (PCR) was used to detect HCMV and EBV genotypes in plaque samples.
Main Results:
- HCMV genotype 2 was found in 53.3% and EBV genotype 1 in 46.6% of peri-implantitis sites.
- These genotypes were rarely detected in healthy peri-implant sites.
- A significant correlation was observed between HCMV-2, EBV-1, and peri-implantitis clinical parameters.
Conclusions:
- HCMV genotype 2 and EBV genotype 1 show high prevalence in peri-implantitis.
- These viruses may play an active role in the pathogenesis of peri-implantitis.
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