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Updated: May 27, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 overexpression impacts on the prognosis of laryngeal squamous cell carcinomas
Mir Mohammad Jalali1, Abtin Heidarzadeh, Mansour Jamali Zavarei
1Otolaryngology, Head and Neck Surgery Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Guilan, Iran. mmjalali@gums.ac.ir
Objectives:
To investigate the prognostic implications of p53 expression in the surgical margins of laryngeal squamous cell carcinomas.
Methods:
Thirty one patients with T3-4N0M0 cancers with pathologically negative margins were analyzed by immunohistochemistry (IHC) to detect expression of p53.
Results:
The p53 positive rates by IHC in the surgical margin were 16.1% (5/31). In the p53 positive margin group, the recurrent rate was higher than those without (80% vs 19.2%, P = 0.006). Also, the median free of disease period in the p53 positive margin group was shorter than other group (22.2 vs 47.8 months, P < 0.0001).
Conclusions:
We found that the overexpression of p53 can serve a prognostic role for both recurrence and disease-specific mortality in head and neck squamous cell carcinoma. p53 expression could stratify patients, in an easy and inexpensive way, according to their risk of local or regional recurrence.
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