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Related Experiment Video

Updated: May 27, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Quad-site pacing using a quadripolar left ventricular pacing lead.

Anoop K Shetty¹, Paresh Mehta, Julian Bostock

¹Guys Hospital and St Thomas' Hospital NHS Foundation Trust, King's College London, London, UK. anoop.shetty@kcl.ac.uk

Pacing and Clinical Electrophysiology : PACE

|December 1, 2011

Summary

Multisite left ventricular pacing may improve cardiac resynchronization therapy (CRT) response. Quad-site pacing, using an additional lead, increased acute hemodynamic response, unlike quadripolar lead pacing alone.

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Area of Science:

Cardiology
Electrophysiology
Medical Devices

Background:

Cardiac resynchronization therapy (CRT) aims to improve heart function by synchronizing ventricular contractions.
Multisite left ventricular (LV) pacing is hypothesized to enhance CRT efficacy.
Quadripolar LV leads offer the potential for multisite pacing.

Observation:

This study investigated the acute hemodynamic response (AHR) to different multisite pacing configurations in CRT.
Pacing was performed using a quadripolar LV lead alone and in combination with other leads.
Hemodynamic parameters, including dP/dt(max), were measured to assess AHR.

Findings:

Multisite pacing using only a quadripolar LV lead did not significantly improve AHR.
"Quad-site" pacing, involving an additional temporary LV lead, demonstrated an increase in dP/dt(max).
This suggests that specific configurations of multisite pacing may be necessary for improved hemodynamic outcomes.

Implications:

The findings suggest that the configuration of LV pacing is critical for optimizing CRT response.
Quad-site pacing may offer a strategy to enhance acute hemodynamic performance in CRT patients.
Further research is warranted to explore the long-term benefits and clinical impact of quad-site pacing.