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Keratinizing squamous dysplasia pap test: a case for colposcopy
Elizabeth W Boggs1, Judy T Burgis, Lisa Beth Spiryda
1Department of Obstetrics and Gynecology, School of Medicine, University of South Carolina, Columbia, SC 29203, USA.
Journal of Lower Genital Tract Disease
|December 1, 2011
Summary
Women with keratinizing squamous dysplasia (KSD) on Pap tests are often older and immunosuppressed. Aggressive management with colposcopy is recommended due to high rates of persistent or progressive cervical disease.
Area of Science:
- Gynecology
- Cervical Pathology
- Cytopathology
Background:
- Keratinizing squamous dysplasia (KSD) is an uncommon finding on Pap tests.
- Management strategies for KSD require further characterization.
Purpose of the Study:
- To characterize women with KSD on Pap tests.
- To inform management strategies for patients with KSD.
Main Methods:
- Retrospective chart review of women with KSD on Pap tests from 1999-2009.
- Statistical analysis of patient demographics and outcomes.
Main Results:
- KSD patients were older, more likely African American, and less likely Hispanic than the general population.
- 41% of women with KSD were immunosuppressed.
- Cervical biopsies showed high-grade squamous intraepithelial lesions (CIN 2/3) or cancer in 58% of cases.
- 80% of women with CIN 1 on biopsy had persistent dysplasia or abnormal Pap tests.
Conclusions:
- Women with KSD on Pap tests should undergo immediate colposcopy and biopsy.
- Aggressive management is indicated, not expectant management.
