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Updated: May 27, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Optimal antiretroviral therapy for aging.

Damien V Cordery¹, David A Cooper

¹The Kirby Institute, University of New South Wales, Sydney, NSW 2010, Australia.

|December 1, 2011

Summary

Highly active antiretroviral therapy (HAART) has improved HIV survival, leading to more older adults living with HIV. Current guidelines lack specific recommendations for managing age-related complications in this growing population.

Area of Science:

Infectious Diseases
Geriatrics
Pharmacology

Background:

Highly active antiretroviral therapy (HAART) has transformed the HIV epidemic, significantly reducing mortality and morbidity.
Increased life expectancy means a growing population of older adults are living with HIV.
Both aging and HIV/HAART are associated with comorbidities like cardiovascular, neurological, kidney, liver, and metabolic complications.

Purpose of the Study:

To highlight the increasing prevalence of HIV in older adults.
To underscore the overlap in health complications associated with aging and HIV/HAART.
To identify the gap in specific treatment guidelines for this demographic.

Main Methods:

Review of current literature on HIV, aging, and associated comorbidities.

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Analysis of the impact of HAART on life expectancy and long-term health outcomes.

Examination of existing clinical management and treatment guidelines for HIV-infected older adults.

Main Results:

HIV-infected individuals are living longer due to HAART, resulting in a larger proportion of older patients.
Comorbidities common in aging are exacerbated or mimicked by HIV infection and HAART.
There is a notable absence of tailored treatment guidelines for managing HIV in the elderly.

Conclusions:

The aging HIV population presents unique and complex clinical challenges.
There is an urgent need for the development of specific guidelines for antiretroviral therapy and clinical management in older adults with HIV.
Addressing age-related comorbidities is crucial for optimizing long-term care and quality of life for aging individuals with HIV.