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Fibrinolytic phenomenon in leprosy
V H Jadhav1, M V Jadhav, S M Sapatnekar
1Dr. Bandorawalla Leprosy Hospital, Kondhawa, Pune.
Indian Journal of Leprosy
|April 1, 1990
Summary
Fibrinolytic activity is significantly reduced in leprosy patients, especially those with lepromatous leprosy and erythema nodosum leprosum (ENL) reactions. This decrease, likely due to cutaneous vasculitis, partially recovers after ENL subsides but remains below normal levels.
Area of Science:
- Hematology
- Immunology
- Dermatology
Background:
- Leprosy, a chronic infectious disease, can affect various systems, including the coagulation and fibrinolytic pathways.
- Erythema nodosum leprosum (ENL) is a common inflammatory complication of leprosy, often associated with systemic manifestations.
- Understanding fibrinolytic activity in leprosy is crucial for managing complications and disease progression.
Purpose of the Study:
- To investigate fibrinolytic activity in patients with different forms of leprosy compared to healthy controls.
- To determine the impact of ENL reactions on fibrinolytic activity.
- To explore the potential causes of altered fibrinolytic activity in leprosy.
Main Methods:
- Euglobulin Lysis Time Method was employed to assess fibrinolytic activity.
- Eighty-one leprosy patients and thirty-two healthy individuals were included in the study.
- Patients presented with various types of leprosy, including those experiencing ENL reactions.
Main Results:
- Fibrinolytic activity was markedly decreased in patients with lepromatous leprosy and those with ENL reactions.
- The decline in fibrinolytic activity during ENL was not dependent on the frequency of ENL attacks.
- Fibrinolytic activity showed partial restoration after ENL subsided but did not reach normal levels.
Conclusions:
- Fibrinolytic activity is significantly impaired in lepromatous leprosy and during ENL reactions.
- Cutaneous vasculitis is suggested as the most probable cause for the observed reduction in fibrinolytic activity.
- While fibrinolysis improves post-ENL, it remains suboptimal, indicating persistent underlyingpathophysiological changes.