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Antihypertensive effect of a fixed-dose combination of losartan/hydrochlorothiazide in patients with uncontrolled

Tatsuo Hosoya1, Satoru Kuriyama, Iwao Ohno

  • 1Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan.

Clinical and Experimental Nephrology
|December 1, 2011
PubMed

Insights

Switching to losartan (LOS) plus hydrochlorothiazide (HCTZ) significantly lowers blood pressure in uncontrolled hypertension patients. This combination therapy may offer cardio- and reno-protective benefits and improve uric acid metabolism.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Pharmacology

Background:

  • Adequate blood pressure (BP) control frequently necessitates multiple antihypertensive medications.
  • Uncontrolled hypertension poses significant health risks, underscoring the need for effective treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy of a fixed-dose combination of losartan (LOS) and hydrochlorothiazide (HCTZ) in patients with uncontrolled hypertension.
  • To determine if LOS/HCTZ provides superior BP reduction compared to previous antihypertensive regimens.

Main Methods:

  • Prospective, multicenter, observational trial involving 228 patients with uncontrolled hypertension.
  • Patients were switched to a single tablet of losartan 50 mg/hydrochlorothiazide 12.5 mg.
  • BP was monitored in clinic and at home.

Main Results:

  • Significant reductions in both systolic and diastolic BP were observed post-switch to LOS/HCTZ.
  • B-type natriuretic peptide (BNP) and urinary albumin-to-creatinine ratio (ACR) decreased significantly, particularly in patients with elevated baseline levels.
  • Serum creatinine (Cr) concentration increased, and estimated glomerular filtration rate (eGFR) decreased.
  • Serum uric acid (UA) concentration increased overall, but decreased in patients with hyperuricemia.

Conclusions:

  • Switching to LOS/HCTZ effectively reduces clinic and home BP in patients with uncontrolled hypertension.
  • This combination therapy shows potential for cardio- and reno-protection.
  • The therapy may positively impact uric acid metabolism.
Abstract

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