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Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...
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Antihypertensive Drugs: Action of β1 Blockers01:17

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Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
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pH buffering does not influence BDNF responses to exercise.

S Rojas Vega1, W Hollmann, B Vera Wahrmann

  • 1German Sport University Cologne, Institute of Movement and Neurosciences, Cologne, Germany. Rojas@dshs-koeln.de

International Journal of Sports Medicine
|December 1, 2011
PubMed
Summary
This summary is machine-generated.

High-intensity exercise increases brain-derived neurotrophic factor (BDNF), independent of acidosis. Buffering pH changes did not alter the BDNF response, suggesting lactate accumulation may directly influence BDNF secretion during intense exercise.

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Area of Science:

  • Exercise Physiology
  • Neuroscience
  • Biochemistry

Background:

  • Acidosis, a condition of excessive acidity, can occur during intense exercise.
  • Brain-derived neurotrophic factor (BDNF) plays a role in neuronal health and plasticity.
  • The relationship between exercise-induced acidosis and BDNF levels is not fully understood.

Purpose of the Study:

  • To investigate the influence of acidosis on BDNF levels during and after high-intensity exercise.
  • To determine if buffering acidosis affects the exercise-induced increase in BDNF.

Main Methods:

  • 11 athletes underwent two trials: one with sodium bicarbonate infusion (to buffer acidosis) and one with a placebo.
  • Exercise protocols included low-intensity (LIE) and high-intensity (HIE) cycling.
  • Blood samples were collected at rest, during exercise, and post-exercise to measure pH, bicarbonate, lactate, and BDNF concentrations.

Main Results:

  • High-intensity exercise (HIE) significantly decreased pH, bicarbonate, and base excess during the placebo trial.
  • Sodium bicarbonate infusion successfully attenuated the fall in pH and bicarbonate during HIE.
  • Serum BDNF levels increased significantly at the end of HIE and remained elevated for 3 minutes post-exercise in both trials.
  • Lactate levels increased identically in both trials, and buffering acidosis did not alter the BDNF response to HIE.

Conclusions:

  • The exercise-induced increase in BDNF during high-intensity exercise appears to be independent of acidosis.
  • Lactate accumulation, rather than acidosis, may be a primary driver of BDNF secretion during intense exercise.
  • These findings suggest a direct role for lactate in modulating BDNF release in response to strenuous physical activity.