Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic substances and cell membrane function.

J B Pritchard

    Federation Proceedings
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Chemicals can harm cell membranes, impacting their function. New techniques reveal how toxic compounds alter membrane proteins and lipids, affecting health and toxicity mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Physiology, structure, and regulation of the cloned organic anion transporters.

    Xenobiotica; the fate of foreign compounds in biological systems·2008
    Same author

    Development and characterization of immobilized human organic anion transporter-based liquid chromatographic stationary phase: hOAT1 and hOAT2.

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2007
    Same author

    Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1.

    Molecular pharmacology·2001
    Same author

    Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus.

    The Journal of biological chemistry·2001
    Same author

    Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells.

    The Journal of pharmacology and experimental therapeutics·2001
    Same author

    Basolateral localization of organic cation transporter 2 in intact renal proximal tubules.

    American journal of physiology. Renal physiology·2000
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    Area of Science:

    • Toxicology
    • Cell Biology
    • Biochemistry

    Background:

    • Cell membranes are vital for cellular function and are exposed to various chemicals.
    • Previous understanding of membrane structure and function was limited.
    • New techniques have advanced the study of membrane complexities.

    Purpose of the Study:

    • To summarize current concepts of cell membrane structure and function.
    • To discuss techniques used for studying cell membranes.
    • To explore how xenobiotics alter membrane function.

    Main Methods:

    • Review of current literature on membrane structure and function.
    • Discussion of methodologies for cell membrane research.
    • Presentation of case studies on xenobiotic-membrane interactions.

    Related Experiment Videos

    Main Results:

    • Toxic compounds can interact with membrane lipids or proteins, altering function.
    • Examples include heavy metals affecting ion permeability and nutrient transport.
    • Organochlorine pesticides impair osmoregulation and calcium transport.
    • Phenoxyacetic acid herbicides inhibit neurotransmitter metabolite transport.

    Conclusions:

    • Understanding xenobiotic interactions with membranes is crucial for deciphering toxicity mechanisms.
    • Studying membrane function provides insights into basic biological processes.
    • Cell membrane research is key to understanding chemical toxicity.