Related Experiment Video
Updated: May 27, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
Published on: February 19, 2016
A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel
Prajakta Dandekar1, Ratnesh Jain, Thomas Stauner
1Organic Macromolecular Chemistry, Saarland University, Saarbrücken, Germany.
Abstract:
A hydrophobic starch derivative is used for safe and enhanced delivery of anticancer agents. The synthesis and characterization of propyl starch with a controlled degree of substitution to modulate the release of the encapsulated hydrophobic drug is reported. The application of this polymer for formulating nanoparticles of docetaxel, an anti-cancer agent effective against numerous types of cancers but possessing intrinsic formulation difficulties is described. The solvent emulsification/diffusion technique is used and the synthesis is optimized with respect to several formulation parameters. Uptake studies with these nanoparticles indicate their enhanced internalization by the cancerous cells and their peri-nuclear localization.
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Drugs that Stabilize Microtubules

