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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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A Practical Guide to Phylogenetics for Nonexperts
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FlyBase 101--the basics of navigating FlyBase.

Peter McQuilton1, Susan E St Pierre, Jim Thurmond

  • 1Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

Nucleic Acids Research
|December 1, 2011
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Summary
This summary is machine-generated.

FlyBase is a key resource for Drosophila melanogaster genetic and genomic data. This review guides users through its website, highlighting new features from the modENCODE project and essential search tools.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Zoology

Background:

  • FlyBase is a primary database for fruit fly genetic and genomic information.
  • Drosophila melanogaster serves as a model organism in biological research.
  • The modENCODE project has generated extensive genome-wide data.

Purpose of the Study:

  • To review the FlyBase website for novice users.
  • To highlight recent developments, including modENCODE data integration.
  • To guide users in navigating Drosophila biological data.

Main Methods:

  • Website organization and Gene Report description.
  • Introduction to search tools, including QuickSearch.
  • Overview of genomic data access via the Genome Browser (GBrowse).

Main Results:

  • The FlyBase website is structured for ease of use.
  • New genome-wide data from modENCODE is integrated.
  • Effective search and browsing tools are available.

Conclusions:

  • FlyBase provides comprehensive resources for Drosophila research.
  • Recent updates enhance access to genome-wide data.
  • The platform supports diverse applications of Drosophila knowledge.