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Published on: January 23, 2017
High prevalence of hearing impairment in HIV-infected Peruvian children
Christina K Chao1, Josephine A Czechowicz, Anna H Messner
1Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Insights
Hearing impairment affects 38.8% of HIV-infected children in Peru. Risk factors include middle ear disease, cerebral infections, and low CD4 counts, highlighting the need for regular hearing checks.
Area of Science:
- Pediatrics
- Infectious Diseases
- Audiology
Background:
- Hearing impairment is a potential complication in children with human immunodeficiency virus (HIV) infection.
- Understanding the prevalence and risk factors is crucial for early detection and intervention.
Purpose of the Study:
- To determine the prevalence of hearing impairment in HIV-infected children in Peru.
- To identify associated risk factors for hearing impairment in this population.
Main Methods:
- A cross-sectional observational study was conducted with 139 HIV-infected children (ages 4-19) in Lima, Peru.
- Hearing was assessed using pure tone audiometry, tympanometry, and otoscopy.
- Data on medical history and socioeconomic factors were collected via surveys and chart reviews.
Main Results:
- The prevalence of hearing impairment was 38.8% (54 out of 139 children).
- Significant risk factors identified include tympanic membrane perforation, abnormal tympanometry, cerebral infection, seizures, and CD4 cell counts below 500 cells/mm³.
Conclusions:
- A high prevalence of hearing impairment (38.8%) was observed in HIV-infected children in Lima, Peru.
- Middle ear disease, prior cerebral infection, and low CD4 cell count are associated with hearing impairment.
- Routine hearing assessments are recommended for HIV-infected children.
Objectives:
To measure the prevalence and to identify risk factors of hearing impairment in human immunodeficiency virus-infected children living in Peru.
Study Design:
Cross-sectional observational study.
Setting:
Two public hospitals and 1 nonprofit center in Lima, Peru, between August 2009 and April 2010.
Subjects:
A total of 139 HIV-infected children, ages 4 to 19 years.
Methods:
Hearing impairment and otologic health were assessed with pure tone audiometry, tympanometry, and otoscopy. The primary outcome was hearing loss, defined as average threshold >25dB for 0.5, 1, 2, and 4 kHz, in one or both ears. Historical and socioeconomic information was obtained through parental survey and medical chart review. Statistical analysis included univariate analysis and multivariate logistic regression.
Results:
Fifty-four (38.8%) of 139 children had hearing impairment. On multivariate analysis, risk factors included: tympanic membrane perforation (odds ratio [OR] 7.08; 95% confidence interval [CI], 1.65-30.5; P = .01), abnormal tympanometry (OR 2.71; 95% CI, 1.09-6.75; P = .03), cerebral infection (OR 11.6; 95% CI, 1.06-126; P = .05), seizures (OR 5.20; 95% CI, 1.21-22.4; P = .03), and CD4 cell count <500 cells/mm(3) (OR 3.53; 95% CI, 1.18-10.5; P = .02).
Conclusions:
The prevalence of hearing impairment in HIV-infected children in Lima, Peru was 38.8%. Middle ear disease, prior cerebral infection, and low CD4 cell count were significantly associated with hearing impairment. The high prevalence of hearing impairment emphasizes the need for periodic hearing assessment in the routine clinical care of HIV-infected children.
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