Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoregulatory activity in human decidua.

Y Kitano1, S Fujisaki, N Nakamura

  • 1Department of Obstetrics and Gynecology, Kumamoto University Medical School.

Nihon Sanka Fujinka Gakkai Zasshi
|July 1, 1990
PubMed
Summary

Decidual extracts from early pregnancy inhibit normal immune cell function. This immunosuppressive activity is linked to large molecular weight substances, likely immunoglobulin G (IgG), suggesting a role in preventing maternal immune rejection of the fetus.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lateromedial gradient of the susceptibility of midbrain dopaminergic neurons to neonatal 6-hydroxydopamine toxicity.

Experimental neurology·1995
Same author

Neurotransmitters for the canine inferior pharyngeal constrictor muscle.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·1995
Same author

p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells.

The Journal of biological chemistry·1995
Same author

Cloning of a new cytokine that induces IFN-gamma production by T cells.

Nature·1995
Same author

A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock.

Infection and immunity·1995
Same author

Adenylyl cyclase activity in human decidua and myometrium during pregnancy and labour.

Journal of reproduction and fertility·1995

Area of Science:

  • Immunology
  • Reproductive Biology
  • Maternal-Fetal Medicine

Background:

  • The maternal immune system must tolerate the semi-allogeneic fetus during pregnancy.
  • The decidua, the specialized uterine lining during pregnancy, plays a crucial role in modulating the maternal immune response.

Purpose of the Study:

  • To identify and characterize immunoregulatory factors in the early human decidua (8-13 weeks gestation).
  • To investigate the potential role of these factors in suppressing maternal immune cell function.

Main Methods:

  • Extraction of factors from decidual tissue and proliferative endometrium.
  • Assay of T-cell mitogen-stimulated peripheral blood mononuclear cells (PBM) proliferation using 3H-thymidine incorporation.
  • Molecular weight estimation via Sephadex G-200 filtration.

Related Experiment Videos

  • Immunoelectrophoresis and affinity chromatography (Sepharose 4B-anti-human IgG) to identify the inhibitory substance.

    • Main Results:

    • Decidual extracts significantly inhibited PBM proliferation compared to endometrial extracts.
    • The majority of inhibitory activity was associated with a high molecular weight fraction.
    • Immunochemical analysis strongly suggested that immunoglobulin G (IgG) or a copurified substance is responsible for the observed immunosuppression.

    Conclusions:

    • Early human decidua contains potent immunosuppressive factors, primarily identified as IgG or associated molecules.
    • These findings support a localized, non-specific suppressor mechanism in the decidua.
    • This mechanism likely contributes to preventing maternal immune rejection of the fetal allograft.