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Related Concept Videos

Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
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Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
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Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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One well-characterized example of receptor-mediated endocytosis is the...
Receptor-Mediated Endocytosis01:20

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
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Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
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Published on: December 7, 2017

Shaping membranes for endocytosis.

M Krauss1, V Haucke

  • 1Institute of Chemistry and Biochemistry, Department of Membrane Biochemistry, Freie Universität Berlin, Takustraβe 6, 14195 Berlin, Germany. mkrauss@chemie.fu-berlin.de

Reviews of Physiology, Biochemistry and Pharmacology
|December 1, 2011
PubMed
Summary

Eukaryotic cells use endocytosis to internalize various substances via distinct pathways. Proteins drive plasma membrane deformation, enabling the uptake of diverse cargoes like nutrients and pathogens.

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Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • Endocytosis is a fundamental cellular process in eukaryotes.
  • It facilitates the uptake of diverse molecules, including nutrients, antigens, pathogens, and receptors.
  • This process is crucial for maintaining cell homeostasis, signaling, and development.

Purpose of the Study:

  • To review the distinct endocytic pathways utilized by various cargoes.
  • To summarize the role of intracellular proteins in membrane deformation during endocytosis.

Main Methods:

  • Literature review of endocytosis mechanisms.
  • Analysis of protein involvement in membrane remodeling.

Main Results:

  • Different cargoes are internalized through specific endocytic routes.
  • Proteins like scaffolding proteins, amphipathic proteins, and lipid-modifying enzymes are key players.
  • These proteins induce the necessary plasma membrane curvature for cargo internalization.

Conclusions:

  • Endocytosis employs diverse, cargo-specific pathways.
  • Protein-mediated membrane deformation is a conserved mechanism across endocytic routes.