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Platelet aggregation in septic shock. Effect of pentoxifylline
J L Ambrus1, J Halpern, M Mahafzah
1Roswell Park Memorial Institute, Buffalo, NY 14263.
Journal of Medicine
|January 1, 1990
Summary
Patients with adult respiratory distress syndrome (ARDS) from septic shock show increased platelet aggregation. Pentoxifylline treatment reduced platelet aggregates, suggesting a disaggregation effect and aiding recovery.
Area of Science:
- Hematology
- Critical Care Medicine
- Pharmacology
Background:
- Adult respiratory distress syndrome (ARDS) in septic shock is associated with abnormal platelet activity.
- Increased platelet aggregation and circulating platelet aggregates are observed in ARDS patients.
Purpose of the Study:
- To investigate the effect of pentoxifylline on platelet aggregation and disaggregation in ARDS patients.
- To explore pentoxifylline's potential therapeutic role in managing septic shock-induced ARDS.
Main Methods:
- In vitro incubation of blood samples with pentoxifylline (Trental).
- Analysis of platelet aggregate patterns before and after treatment.
- Clinical observation of patients during recovery.
Main Results:
- Pentoxifylline significantly decreased platelet aggregates in vitro.
- The drug demonstrated a platelet disaggregation effect beyond simple inhibition.
- Platelet aggregate patterns normalized within two weeks of clinical recovery.
Conclusions:
- Pentoxifylline exhibits both anti-platelet aggregation and platelet disaggregation properties.
- These findings suggest pentoxifylline as a potential therapeutic agent for ARDS associated with septic shock.
- Restoration of normal platelet function correlates with clinical improvement in ARDS.