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Amyloid-β peptide structure in aqueous solution varies with fragment size

Olivia Wise-Scira1, Liang Xu, Taizo Kitahara

  • 1The University of Texas at San Antonio, Department of Chemistry, One UTSA Circle, San Antonio, Texas 78249, USA.

The Journal of Chemical Physics
|December 2, 2011
PubMed
Summary

Amyloid-beta (Aβ) fragments Aβ16 and Aβ28 do not fully replicate the structural and thermodynamic properties of full-length Aβ42 peptides in solution. Their secondary structures differ significantly, limiting their use as complete mimics.

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