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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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Related Experiment Video

Updated: May 27, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Spirometric obstructive lung function pattern early after lung transplantation.

Hendrik Suhling1, Sabine Dettmer, Jessica Rademacher

  • 1Department of Pulmonary Medicine, Hannover Medical School, Hannover, Germany. suhling.hendrik@mh-hannover.de

Transplantation
|December 2, 2011
PubMed
Summary
This summary is machine-generated.

An early obstructive lung function pattern after lung transplantation (LTx) is linked to a higher risk of bronchiolitis obliterans syndrome (BOS) and poorer outcomes. This pattern may indicate donor lung injury, impacting long-term survival.

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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
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10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Area of Science:

  • Pulmonary Medicine
  • Transplantation Immunology
  • Respiratory Physiology

Background:

  • Obstructive spirometry patterns are common post-lung transplantation (LTx) and can stem from various causes.
  • Investigating the impact of early obstructive patterns on transplant recipient outcomes is crucial.

Purpose of the Study:

  • To assess the clinical impact and outcomes associated with an early obstructive spirometric pattern in lung transplant recipients.
  • To determine if early obstructive patterns predict the development of bronchiolitis obliterans syndrome (BOS).

Main Methods:

  • A cohort of double lung transplant (LTx) recipients were classified based on spirometry 3 months post-transplant (obstructive: FEV(1):VC <0.7; non-obstructive: FEV(1):VC ≥0.7).
  • Analysis included pulmonary function, bronchoscopy, lab parameters, CT morphology, mortality, and BOS-free survival up to 36 months.
  • Donor lung characteristics (age, smoking history, blood gases) were also collected.

Main Results:

  • 17% of recipients showed an early obstructive pattern.
  • Obstructive recipients were older, had lower FEV(1), higher TLC, and received donor lungs with lower pO(2).
  • Obstructive patients experienced earlier peak FEV(1) and significantly higher BOS development (47% vs. 14%).

Conclusions:

  • An early obstructive lung function pattern post-LTx is associated with accelerated BOS development.
  • This pattern negatively impacts outcomes after double LTx and may signal structural donor lung injury.