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Updated: May 27, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Impulsivity and functional impairment in bipolar disorder.

E Jiménez¹, B Arias, P Castellví

¹Bipolar Disorder Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Journal of Affective Disorders

|December 2, 2011

Summary

Impulsivity, depressive symptoms, and hospitalizations are linked to functional impairment in bipolar patients (BP). Addressing impulsivity may improve functional outcomes for individuals with BP.

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Area of Science:

Psychiatry
Neuroscience
Clinical Psychology

Background:

Impulsivity is elevated in bipolar patients (BP) and may correlate with illness severity.
Previous research has not explored the link between impulsivity and functional outcomes in BP.
This study aimed to determine the functional impact of trait-impulsivity in BP.

Purpose of the Study:

To investigate the relationship between trait-impulsivity and functional outcome in euthymic bipolar patients.
To identify predictors of functional impairment in bipolar disorder.

Main Methods:

138 euthymic bipolar patients were assessed using the Structured Clinical Interview for DSM Disorders (SCID).
Functional outcome was measured using the Functioning Assessment Short Test (FAST), and impulsivity was assessed with the Barratt Impulsiveness Scale (BIS-11).
Multiple linear regressions were performed to evaluate the predictive role of trait-impulsivity on FAST scores.

Main Results:

Depressive symptoms (β=1.580; p<0.001), number of hospitalizations (β=0.837; p=0.019), and impulsivity (β=0.319; p=0.004) were independently associated with overall functional impairment.
The regression model explained 31.1% of the variance in functional impairment (adjusted R2=0.311).

Conclusions:

Impulsivity is associated with overall functional impairment in bipolar patients, alongside depressive symptoms and hospitalization history.
Assessing and treating impulsivity may be beneficial for improving functional outcomes in bipolar disorder.
The study's cross-sectional design limits causal inferences.