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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

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Related Experiment Video

Updated: May 27, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

[Basal cell carcinoma: often more than one].

Sophie C Flohil1, Senada Koljenović, Ellen R M de Haas

  • 1Erasmus MC Universitair Medisch Centrum, Rotterdam, Afd. Dermatologie, the Netherlands.

Nederlands Tijdschrift Voor Geneeskunde
|December 2, 2011
PubMed
Summary

Nearly one-third of patients with basal cell carcinoma (BCC) develop multiple lesions, with higher risks observed in men and older individuals. Early detection and regular skin exams are crucial for managing BCC recurrence.

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Cell Population Analyses During Skin Carcinogenesis
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Related Experiment Videos

Last Updated: May 27, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Basal cell carcinoma (BCC) is the most common type of skin cancer.
  • Understanding the risk of developing multiple BCCs is crucial for patient management and prognosis.

Purpose of the Study:

  • To determine the cumulative incidence and risk of developing multiple (two or more) basal cell carcinomas (BCCs).
  • To investigate the influence of gender and age on the risk of multiple BCC development.

Main Methods:

  • Retrospective cohort study utilizing nationwide histopathology data from the Netherlands (PALGA).
  • Analysis of 2483 patients diagnosed with their first BCC in 2004, followed for five years.
  • Andersen-Gill survival analysis to assess risk factors for multiple BCC development.

Main Results:

  • The five-year cumulative risk of developing multiple BCCs was 29.2%.
  • Men had a 30% higher risk, and individuals aged 65-79 had an 80% higher risk compared to younger patients.
  • The incidence rate of multiple BCCs was highest in the first year after initial diagnosis.

Conclusions:

  • A significant proportion of BCC patients develop subsequent lesions, particularly within the first year post-diagnosis.
  • Recommendations include comprehensive skin examinations at BCC diagnosis and annual follow-ups for at least three years.